Information on the antifolate drug pemetrexed  
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Pemetrexed Research

There is a lot of research going on with regard to pemetrexed.

Phase II study of pemetrexed in patients with advanced neuroendocrine tumors.

A phase-I trial of pemetrexed plus carboplatin in recurrent ovarian cancer.

Use of pemetrexed in breast cancer

Pemetrexed pharmacokinetics and pharmacodynamics in a phase I/II study of doublet chemotherapy with vinorelbine: implications for further optimisation of pemetrexed schedules

Pemetrexed in advanced non-small-cell lung cancer.

In vitro synergistic cytotoxicity of gemcitabine and pemetrexed and pharmacogenetic evaluation of response to gemcitabine in bladder cancer patients.

Phase II study of pemetrexed plus carboplatin in malignant pleural mesothelioma.

The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier.

Dramatic tumour response to pemetrexed single-agent in an elderly patient with malignant peritoneal mesothelioma: a case report

A phase I study of pemetrexed (LY231514) supplemented with folate and vitamin B12


Pemetrexed single agent chemotherapy in previously treated patients with locally advanced or metastatic non-small cell lung cancer.


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